If even one went wrong, or was at all ambiguous, I was going to be in a hell of a lot of trouble. Not only had I never heard of BAIDU ( 12D: Major Chinese internet company) or RELAXIN, I had no way of inferring any part of those answers, any single letter, and so working the crosses was really harrowing. It makes the theme a lot easier to crack than usual, but the difficult-ish cluing overall, as well as two terms I've never seen in my life, made the overall solving experience reasonably Thursday-ish in the end. It puts the theme into the mix, allowing it to be visible and relevant to the solve throughout the puzzle instead of just something you notice at the end. I can imagine the theme clues being written with the first part dropped entirely, such that the revealer would cause you to look back and notice, "oh, right, those are indeed two sounds mixed together," but I think it's more fun to have the weird sound equation thing going on. The equation gimmick is clever, even if the themers do end up essentially double-clued. But MIXING much better expresses the whole sound equation thing happening in the theme clues today, which I think basically works-that is, these themers are all phrases made out of the combination ("mixing") of two sounds. I didn't know SOUND MIXING was an Academy Award to begin with, so the MIXING part was weirdly hard for me to get at the end. In the male, it is produced in the prostate and is present in human semen. In the female, it is produced by the corpus luteum of the ovary, the breast and, during pregnancy, also by the placenta, chorion, and decidua. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity relaxin-1 (RLN1), 2 (RLN2) and 3 ( RLN3), and the insulin-like (INSL) peptides, INS元, INSL4, INSL5 and INSL6. Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw. Word of the Day: RELAXIN ( 44D: Pregnancy hormone). as equations following this pattern: + = : or a hint to interpreting four clues in this puzzle) - familiar two-word (or two-part) phrases clued as the "mixing" of two "sounds," i.e. THEME: SOUND MIXING (57A: Academy Awards category eliminated in 2021.
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